Regulation of human gut B lymphocytes by T lymphocytes.
Open Access
- 1 January 1984
- Vol. 25 (1), 47-51
- https://doi.org/10.1136/gut.25.1.47
Abstract
The aims of this study were first, to assess whether or not immunoglobulin secretion from human gut mucosal B lymphocytes can be modified by T lymphocytes, and second whether human gut mucosal T lymphocytes are capable of regulating mucosal B lymphocyte function. T and B lymphocyte enriched cell populations were isolated from gut mucosa and co-cultured in varying proportions. Addition of T lymphocytes to B enriched mucosal cell populations (ratio B:T = 2:1) showed that mucosal B lymphocytes were responsive to T cell 'help'. Addition of more T cells (ratio B:T = 2:10) suppressed immunoglobulin synthesis.This publication has 29 references indexed in Scilit:
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