THE EFFECT OF CHOLESTYRAMINE ON SERUM LIPIDS AND PLATELET AGGREGATION OF HYPERCHOLESTEROLEMIC CHILDREN (TYPE 11A) WHILE ON HIGH LINOLEIC ACID DIET

Abstract

Children (25) with familial hypercholesterolemia (type II A) were treated with cholestyramine or placebo in a cross over study during 2 periods of 10 wk each. Medication was added to a high linoleic acid diet which was started at least 1 yr earlier. Serum lipids and platelet aggregation were investigated at the end of the 2 periods. On cholestyramine, serum cholesterol levels decreased significantly; the linoleate and oleate content of cholesterylesters and serum triglycerides did not change systematically. Platelet aggregation time measured with a filtragometer did not systematically change either.