RESERPINE-HYDRALAZINE COMBINATION THERAPY OF HYPERTENSIVE DISEASE, WITH HYDRALAZINE IN DOSES GENERALLY BELOW THE "TOXIC RANGE"

Abstract

Hydralazine in daily doses of 300 mg or less, when combined with reserpine, produced a significant hypo-tensive effect in a large majority of patients with fixed hypertension of over 3 years'' duration. Therapeutic effectiveness was attained without significant toxicity. This is in accord with the impression that the incidence of toxicity is at least partly a function of dosage. Reserpine alone produces a significant hypotensive effect in certain patients with fixed and prominent hypertension.