INCREASED RENAL PHOSPHATE EXCRETION IN CUSHING'S SYNDROME

Abstract

Renal phosphate excretion was measured in 23 cases of Cushing''s syndrome using the phosphate excretion index (PEI) described by Nordin and Fraser (1960). The majority of the patients had an increased PEI associated with a tendency towards hypo-phosphoraemia. Regression of the syndrome due to intrasellar implantation of 90Y or to removal of an adrenal neoplasm led to prompt correction of both the PEI and the phosphoraemia. In patients with adrenal insufficiency the PEI values fell below the lower limit of the normal.