Choleretic and cholestatic effects of infused bile salts in the rat
- 1 June 1979
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 35 (6), 809-811
- https://doi.org/10.1007/bf01968265
Abstract
In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20–50%. However, at high infusion rates (5–20 μmoles min−1 kg−1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC>TCDC>TC.Keywords
This publication has 23 references indexed in Scilit:
- Hepatic Excretory Transport Maximum for Free and Conjugated Cholate in the Rat1Published by S. Karger AG ,2015
- Hepatic Bile FormationNew England Journal of Medicine, 1976
- Taurocholate excretion and bile formation in the isolated perfused rat liverNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1974
- Comparison of the choleretic properties of bile acidsEuropean Journal of Pharmacology, 1973
- Biochemical and Morphological Parameters of Taurolithocholate-Induced CholestasisCanadian Journal of Physiology and Pharmacology, 1971
- Serum bile acids in liver diseaseGut, 1971
- Mechanism of cholestasis. 2. Effect of bile acids on the microsomal electron transfer system in vitroLife Sciences, 1970
- Mechanism of cholestasis. 1. Effect of bile acids on microsomal cytochrome P-450 dependent biotransformation system in vitroLife Sciences, 1970
- CHOLESTASIS IS THE RESULT OF HYPOACTIVE HYPERTROPHIC SMOOTH ENDOPLASMIC RETICULUM IN THE HEPATOCYTEThe Lancet, 1969
- Effect of sodium taurolithocholate on bile flow and bile acid excretionJCI Insight, 1968