THE URINARY EXCRETION OF ESTROGENS, ANDROGENS AND FSH FOLLOWING THE ADMINISTRATION OF TESTOSTERONE TO HUMAN FEMALE CASTRATES

Abstract

Testosterone propionate was administered to 4 human [female] castrates who had severe vasomotor symptoms. All had symptomatic relief and revealed changes in the vaginal smear toward the cornified type. Assays of the 24-hr. urine specimen showed a moderate to marked increase in the output of total estrogens, a slight rise in the androgens and a decrease in the FSH levels. There seemed to be a definite correlation between the laboratory findings and the clinical changes.