Gadolinium (III) complex equilibria: The implications for Gd(III) MRI contrast agents
- 1 October 1990
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 16 (1), 57-66
- https://doi.org/10.1002/mrm.1910160107
Abstract
A computer model of blood plasma which has allowed the effect of Gd(III) contrast agents to be simulated has been developed. Initial binding of Gd(III) is to transferrin. At high concentration the metal ion binds to citrate and salicylate. At a concentrate of 10−3 M, GdCl3 is predicted to effect a redistribution of the in vivo Zn(II), Ca(II), and Fe(II) complexes present in blood plasma. There is little effect on the Cu(II) distribution. At a concentration below lo−5 M EDTA and DTPA have little effect on the free Gd(III) metal ion concentration. Above this concentration though, the metal ion is bound aimost exclusively to the EDTA or DTPA. An attempt is made to relate the toxicity of GdCl3, [Gd(EDTA)]−, and [Gd(DTPA)]2− to the thermodynamic stability of these complexes. The effect of substitution kinetics is also discussed. © 1990 Academic Press, Inc.This publication has 28 references indexed in Scilit:
- Tissue distribution and stability of metalloporphyrin MRI contrast agentsMagnetic Resonance in Medicine, 1987
- Relaxation of water protons in the intra‐ and extracellular regions of blood containing Gd(DTPA)Magnetic Resonance in Medicine, 1986
- The Tissue Proton T1 and T2 Response to Gadolinium DTPA Injection in Rabbits A Potential Renal Contrast Agent for NMR ImagingInvestigative Radiology, 1984
- Stability constants and thermodynamic functions of Gd(III), Tb(III), Dy(III), Ho(III) and Y(III) chelates with glutamic acidThermochimica Acta, 1981
- Thermodynamics for the formation of cysteinate complexes of lanthanide(III) ionsJournal of the Less Common Metals, 1980
- Affinity of lanthanoid(III) ions for nitrogen-donor ligands in aqueous solutionJ. Chem. Soc., Dalton Trans., 1979
- Computer simulation of chelation therapy Plasma mobilizing index as a replacement for effective stability constantFEBS Letters, 1977
- Computer simulation of metal-ion equilibria in biofluids: models for the low-molecular-weight complex distribution of calcium(II), magnesium(II), manganese(II), iron(III), copper(II), zinc(II), and lead(II) ions in human blood plasmaJ. Chem. Soc., Dalton Trans., 1977
- Liquid Metals: Chemistry and PhysicsJournal of the Electrochemical Society, 1973
- On the Structure-Dependent Behavior of Ethylenediaminetetraacetato Complexes of the Rare Earth Ln3+ Ions1Journal of the American Chemical Society, 1965