Yeast cell-cycle mutantcdc21 is a temperature-sensitive thymidylate auxotroph
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 146 (3), 313-315
- https://doi.org/10.1007/bf00701257
Abstract
Genetic tests with the yeast cell-cycle mutantcdc21 isolated by Hartwell indicate that the CDC21 gene in yeast is the same as the TMP1 gene, whose mutant alleles confer an auxotrophic requirement for thymidine-5′-monophosphate (dTMP). Yeast strains carryingcdc21 can grow at 37° in the presence of dTMP provided that they are permeable to this compound. The gene is shown to be linked toade2 on Chr. XV, and a case of intragenic complementation betweencdc21 and anothertmp1 allele is reported.This publication has 13 references indexed in Scilit:
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