Bacterial proteins binding to the mammalian extracellular matrix
- 1 August 1993
- journal article
- research article
- Published by Wiley in Molecular Microbiology
- Vol. 9 (4), 687-694
- https://doi.org/10.1111/j.1365-2958.1993.tb01729.x
Abstract
Pathogenic bacteria frequently express surface proteins with affinity for components of the mammalian extracellular matrix, i.e. collagens, laminin, fibronectin or proteoglycans. This review summarizes our current knowledge on the mechanisms of bacterial adherence to extracellular matrices and on the biological significance of these interactions. The best‐characterized bacterial proteins active in these interactions are the mycobacterial fibronectin‐binding proteins, the fibronectin‐ and the collagen‐binding proteins of staphylococci and streptococci, specific enterobacterial fimbrial types, as well as the polymeric surface proteins YadA of yersinias and the A‐protein of Aeromonas. Some of these bacterial proteins are highly specific for an extracellular matrix protein, some are multifunctional and express binding activities towards a number of target proteins. The interactions can be based on a protein‐protein or on a protein‐carbohydrate interaction, or on a bridging mechanism mediated by a bivalent soluble target protein. Many of the interactions have also been demonstrated on tissue sections or in vivo, and adherence to the extracellular matrix has been shown to promote bacterial colonization of damaged tissues.Keywords
This publication has 85 references indexed in Scilit:
- P Fimbriae of Uropathogenic Escherichia coli as Multifunctional Adherence OrganellesZentralblatt für Bakteriologie, 1993
- Binding of bacterial adhesins to rat glomerular mesangium in vivoKidney International, 1993
- Penetration of fimbriate enteric bacteria through basement membranes: A hypothesisFEMS Microbiology Letters, 1992
- The Crl protein activates cryptic genes for curli formation and fibronectin binding in Escherichia coli HB101Molecular Microbiology, 1992
- Multiple binding sites in fibronectin and the staphylococcal fibronectin receptorEuropean Journal of Biochemistry, 1992
- CHAPERONE-ASSISTED ASSEMBLY AND MOLECULAR ARCHITECTURE OF ADHESIVE PILIAnnual Review of Microbiology, 1991
- Type V collagen as the target for type‐3 fimbriae, enterobacterial adherence organellesMolecular Microbiology, 1990
- Fibronectin-mediated Calmette-Guerin bacillus attachment to murine bladder mucosa. Requirement for the expression of an antitumor response.JCI Insight, 1990
- The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen‐binding proteinMolecular Microbiology, 1989
- A novel lectin‐independent interaction of P fimbriae of Escherichia coli with immobilized fibronectinFEBS Letters, 1989