Antibodies to Cerebroside Sulfate Inhibit the Effects of Morphine and β-Endorphin
- 4 January 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4426), 75-76
- https://doi.org/10.1126/science.6243189
Abstract
Morphine and beta-endorphin inhibit the shaking response of pentobarbital-anesthetized rats to ice water. Stereotaxically guided administration of antibodies to cerebroside sulfate into the periaqueductal gray region, the most sensitive brain region in which to demonstrate inhibition of this response, antagonizes the effect of morphine and beta-endorphin. These results suggest that cerebroside sulfate may be an integral component of an opiate receptor in rat brain.Keywords
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