All You Need Is RNA
- 31 July 1998
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 281 (5377), 658-659
- https://doi.org/10.1126/science.281.5377.658
Abstract
What does it take to string amino acids together to form a protein? This essential process of life, synthesis of peptide bonds, can be accomplished by naked RNA molecules, as Schimmel and Alexander explain in their Perspective. This notion, bolstered by the results of [ Nitta et al. ][1] in this week's issue, paints a picture of how the first proteins may have been synthesized in an ancient world where RNA molecules were the precursors of life. [1]: http://www.sciencemag.org/cgi/content/short/281/5377/666This publication has 11 references indexed in Scilit:
- Reconstitution of Peptide Bond Formation with Escherichia coli 23 S Ribosomal RNA DomainsScience, 1998
- Peptide bond formation by in vitro selected ribozymesNature, 1997
- A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosomeNature, 1995
- Efficient aminoacylation of resected RNA helices by class II aspartyl-tRNA synthetase dependent on a single nucleotide.The EMBO Journal, 1994
- An operational RNA code for amino acids and possible relationship to genetic code.Proceedings of the National Academy of Sciences, 1993
- Unusual Resistance of Peptidyl Transferase to Protein Extraction ProceduresScience, 1992
- Overlapping Nucleotide Determinants for Specific Aminoacylation of RNA MicrohelicesScience, 1992
- Ribosomal proteins L15 and L16 are mere late assembly proteins of the large ribosomal subunit. Analysis of an Escherichia coli mutant lacking L15.Journal of Biological Chemistry, 1990
- Localisation of a series of intra–RNA cross-links in the secondary and tertiary structure of 23S RNA, induced by ultraviolet irradiation ofEscherichia50S ribosomal subunitsNucleic Acids Research, 1983
- Secondary structure model for 23S ribosomal RNANucleic Acids Research, 1981