Modern Concepts in Immune Recognition and Lymphocyte Activation: Relevance for the Development of Useful Vaccines
- 1 January 1994
- journal article
- Published by Cambridge University Press (CUP) in International Journal of Technology Assessment in Health Care
- Vol. 10 (1), 81-92
- https://doi.org/10.1017/s026646230001401x
Abstract
Adaptive immunity requires both specific recognition of an antigen and its translation into appropriate lymphocyte responses. This paper reviews the striking differences in B- and T-lymphocyte antigen recognition, details the pathways for conversion of protein antigens into peptide–major histocompatibility complex molecule ligands for T-cell receptors, and summarizes the roles of costimulatory signals in lymphocyte activation. This information is used to suggest new approaches for the rational design of vaccines.Keywords
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