Intravascular Coagulation in the Development of Massive Hepatic Necrosis Induced byCorynebacterium parvumand Endotoxin in Rats
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 24 (3), 293-298
- https://doi.org/10.3109/00365528909093049
Abstract
When Escherichia coli endotoxin was intravenously injected into rats given killed Corynebacterium parvum 6 days previously, fibrin deposition and endothelial cell injury occurred in hepatic sinusoids at 1.5 h and were intensified thereafter. Serum alanine aminotransferase values were increased along with prothrombin time and decreased plasma levels of antithrombin III and coagulation factor VIII:C at 5h. Antithrombin III concentrate (plus heparin) or superoxide dismutase infused concurrently with injection of endotoxin significantly attenuated the derangements of these variables and the histologic extent of liver injury at 5 h. Intravascular coagulation, probably developing through the action of superoxide anion, may contribute to the development of massive hepatic necrosis induced by C. parvum and endotoxin in rats.This publication has 13 references indexed in Scilit:
- Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III.Gut, 1988
- FORMAZAN FORMATION IN HEPATIC MACROPHAGES AFTER NITRO BLUE TETRAZOLIUM PERFUSION INTO RAT LIVER Biomedical Research, 1988
- The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis modelHepatology, 1987
- Corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident kupffer cells in the ratGastroenterology, 1986
- Oxygen-derived free radicals promote hepatic injury in the ratGastroenterology, 1985
- Human vascular smooth muscle cells and endothelial cells lack catalase activity and are susceptible to hydrogen peroxideInflammation, 1985
- Deleterious effects of endotoxin on cultured endothelial cells: An in vitro model of vascular injuryInflammation, 1981
- Protection of mice against endotoxin-induced liver damage by anti-inflammatory drugsInflammation Research, 1979
- ROLE OF MONONUCLEAR INFILTRATING CELLS IN PATHOGENESIS OF HEPATITISThe Lancet, 1978
- Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.JCI Insight, 1978