Prophylactic Antibiotic Therapy in X-Irradiated Animals

Abstract

Streptomycin treatment following irradiation in mice gave favorable survival results in about half of the weaning batches studied over a period of 16 mos. Treatments with other antibiotics and results with rats and guinea pigs were less favorable. Wt. changes of successfully treated mice are shown. Streptomycin blood levels and toxicity were essentially the same in irradiated and control mice. The incidence of diarrhea was reduced in rats treated with streptomycin or terramycin, but not with penicillin.