Inducibility of human β-interferon gene in mouse L-cell clones
- 1 June 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 297 (5868), 650-654
- https://doi.org/10.1038/297650a0
Abstract
Transfer of a 36-kilobase piece of human DNA containing the .beta.-interferon (IFN-.beta.) gene into mouse Ltk- cells leads to transient expression of human interferon even without an exogenous inducer. A low level of human interferon expression is also found in most stable clones containing the transferred DNA. With double-stranded RNA or Newcastle disease virus (NDV) as inducer, human interferon expression is greatly increased. The induced transcript is identical to normal human IFN-.beta. mRNA. Neighboring genes contained on the transferred DNA are co-induced but are not essential for the production of human interferon in mouse L cells.This publication has 34 references indexed in Scilit:
- The identity of interferon‐β1 mRNA transcripts in human fibroblasts and namalva cellsFEBS Letters, 1982
- Gene shuttling: moving of cloned DNA into and out of eukaryotic cellsNucleic Acids Research, 1982
- Analysis of interferon mRNA in human fibroblast cells induced to produce interferon.Proceedings of the National Academy of Sciences, 1981
- The structure of a thirty-six kilobase region of the human chromosome including the fibroblast interferon gene IFN-βNucleic Acids Research, 1981
- Synthesis of new proteins associated with the induction of interferon in human fibroblast cells.Proceedings of the National Academy of Sciences, 1980
- Transformation of mammalian cells with genes from procaryotes and eucaryotesCell, 1979
- The Interferon SystemPublished by Springer Nature ,1979
- Superinduction of Interferon with Metabolic Inhibitors: Possible Mechanisms and Practical ApplicationsThe Journal of Infectious Diseases, 1976
- Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.Proceedings of the National Academy of Sciences, 1967
- Tyrosine Transaminase Induction in Mammalian Cells in Tissue CulturePublished by Cold Spring Harbor Laboratory ,1966