Catabolite repression in Escherichia coli mutants lacking cyclic AMP receptor protein.
- 1 October 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (10), 5799-5801
- https://doi.org/10.1073/pnas.77.10.5799
Abstract
Pleiotropic carbohydrate-positive pseudorevertants were isolated from a specific class of rho-crp double mutants of E. coli carrying both defective transcription termination protein, rho and cAMP receptor protein. The modulation of catabolite repression of .beta.-galactosidase, amylomaltase and tryptophanase was studied in the pseudorevertants. These mutants exhibit catabolite repression. Because catabolite-sensitive operons can be expressed in the absence of functional cAMP receptor protein, this would suggest that the cAMP-receptor protein complex is not the exclusive mediator of catabolite repression and that rho might be involved in the regulation of catabolite-sensitive operons.This publication has 15 references indexed in Scilit:
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