Rôles of Surface Factor and a Plasma Inhibitory Activity (Anti-SF) During Experimental Thrombosis in Rabbits
- 1 January 1964
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 12 (02), 489-504
- https://doi.org/10.1055/s-0038-1655589
Abstract
Intravenous injection of active surface factor (SF) preparations, in rabbits, induces a thrombotic tendency, which correlates with a hypercoagulability of the blood revealed with the thrombelastograph. These effects are largely dissipated within 10 minutes post-injection. Portal vein injections, or confirmed occlusion of the liver circulation, fail to show that the SF inactivation has any direct connection with the liver. Rabbit plasma normally contains a high titer of inhibitor (anti-SF), which shows no significant increase after the SF injections. The inhibition is chiefly “progressive” in rabbit plasma. Plasma anti-SF could largely explain the nonpersistence of hypercoagulability and thrombo-genic activity in the 10 min post-injection tests. These mechanisms may be an important element in the body defenses against any thrombotic tendency associated with increased SF activity. * Aided by USPHS Research Grant HE-01510-11 and NIH-(UNC) Institutional Research Grant HE-06350-03 for Thrombosis Research. ** Present Address: Department of Medicine, Athena Clinic, Victoros Hugo 12, Athinai, Greece.Keywords
This publication has 7 references indexed in Scilit:
- THE THROMBOTIC ACTIVITY OF ACTIVATION PRODUCT*JCI Insight, 1962
- A Two-Stage Assay Method for Hageman Factor ActivityThrombosis and Haemostasis, 1961
- Serum-Induced ThrombosisCirculation, 1959
- Biologic assay of a thrombosis-inducing activity in human serumJournal of Applied Physiology, 1959
- A Simple One-Stage Method for the Assay of Antihemophilic a Factor with a Comment on the Plasma Level of this Factor in Hemophilia AScandinavian Journal of Clinical and Laboratory Investigation, 1959
- Initiation of blood coagulation by glass and related surfacesThe Journal of Physiology, 1957
- Evaluation of ThrombelastographyAmerican Journal of Clinical Pathology, 1955