Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers
- 1 September 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 67 (1), 180-184
- https://doi.org/10.1073/pnas.67.1.180
Abstract
Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic.polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.Keywords
This publication has 7 references indexed in Scilit:
- Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen.1970
- INHIBITION OF HERPES SIMPLEX VIRUS BY SYNTHETIC DOUBLE-STRANDED RNA (POLYRIBOADENYLIC AND POLYRIBOURIDYLIC ACIDS AND POLYRIBOINOSINIC AND POLYRIBOCYTIDYLIC ACIDS)Proceedings of the National Academy of Sciences, 1969
- INHIBITION OF TUMOR GROWTH BY POLYINOSINIC-POLYCYTIDYLIC ACIDProceedings of the National Academy of Sciences, 1969
- Notizen: Uptake of Polynucleotides by Intact Mammalian Cells (IV: Synthetic HomoribopolynucleotidesZeitschrift für Naturforschung B, 1968
- Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.Proceedings of the National Academy of Sciences, 1967
- Screening steroids against a spectrum of tumors.1958
- FASTING KETOSIS IN THE ADRENALECTOMIZED AND CORTISONE-TREATED RATEndocrinology, 1954