FASTING KETOSIS IN THE ADRENALECTOMIZED AND CORTISONE-TREATED RAT
- 1 November 1954
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 55 (5), 593-600
- https://doi.org/10.1210/endo-55-5-593
Abstract
Cortisone treatment inhibits ketonemia and elevates the blood sugar during a 10-day fast in normal rats. Adrenalectomized rats maintained with saline alone exhibit significantly less ketonemia and have lower blood sugars during a 4 day fast than do normal or cortisone maintained adrenalectomized rats. Adrenalectomized rats maintained with DOCA exhibit hyperketonemia and hypoglycemia during a 4 day fast. Cortisone treatment restores the ketonemia and glycemia of adrenalectomized rats to normal.Keywords
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