Quantifying misclassification bias in cohort studies of vaccine efficacy
- 1 November 1990
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 9 (11), 1327-1337
- https://doi.org/10.1002/sim.4780091110
Abstract
A simple mathematical model is presented to quantify the bias due to misclassification in prospective cohort studies of vaccine efficacy. Limitations of methods based on quantifying misclassification in 2 × 2 tables are discussed. The model is applied to data from three examples of the design and analysis of studies of pertussis vaccine efficacy.Keywords
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