A rat brain cDNA encoding the neurotransmitter transporter with an unusual structure
Open Access
- 4 January 1993
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 315 (2), 114-118
- https://doi.org/10.1016/0014-5793(93)81145-p
Abstract
A rat cDNA clone encoding the novel membrane protein of the neurotransmitter transporters family was cloned and sequenced. The cDNA was identified as a transcript of the gene NTT4 of which a partial genomic clone was previously sequenced. Alignment of the amino acid sequence of NTT4 with other members of the neurotransmitter transport family revealed a marked deviattion from the conserved structure of all other members of the family. The largest extracellular loop with a potential glycosylation site was identified between membrane segments 7 and 8. The protein retains the common glycosylated loop between transmembrane helices 3 and 4 in all members of the family. The transcript of NTT4 was found exclusively in the central nervous system and is more abundant in the cerebellum and the cerebral cortex.Keywords
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