THE RAPID PRODUCTION OF ANTISERA AGAINST ATTENUATED POLIOVIRUSES

Abstract

Culture fluids obtained after infection of human kidney cells with Sabin's attenuated strains of polioviruses contained 10⁷ to 10⁸ plaque-forming units per milliliter. When four intravenous injections of such fluids were administered during 6 weeks to rabbits or roosters, the antisera obtained were capable of neutralizing equal volumes of undiluted vaccines.