Evaluation of Human and Simian Immunodeficiency Virus Plaque and Neutralization Assays
- 1 December 1989
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 70 (12), 3327-3333
- https://doi.org/10.1099/0022-1317-70-12-3327
Abstract
Summary A number of CD4+ T cell lines were compared for their ability to act as target cells for human immunodeficiency virus (HIV) infection in syncytium- and plaque-forming assays. MT-4 and C8166 cells were the most sensitive indicator cells for HIV- and simian immunodeficiency virus (SIV)-induced cytopathic effects, and gave rise to macroscopic (MT-4) and microscopic (C8166) plaques. The MT-4 plaque assay was evaluated for the measurement of HIV- and SIV-neutralizing antibodies.Keywords
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