Minor‐groove binders are inhibitors of the catalytic activity of DNA gyrases
- 8 February 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 317 (1-2), 157-162
- https://doi.org/10.1016/0014-5793(93)81513-y
Abstract
Non‐intercalating DNA minor‐groove binders may effectively inhibit the supercoiling activity of gyrases by influencing the enzyme recognition and cleavage site on DNA. For gyrase from Streptomyces noursei a wide range of inhibitory potency for different classes of ligands is observed. This can be explained by a number of structural and binding factors of the ligands competing with the gyrase on the target site of DNA, the mechanism of which is different from the classical gyrase inhibitors.Keywords
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