UNUSUAL PROPERTIES OF HYALURONATEPROTEIN ISOLATED FROM PATHOLOGICAL SYNOVIAL FLUIDS*
Open Access
- 1 December 1963
- journal article
- research article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 42 (12), 1882-1889
- https://doi.org/10.1172/jci104873
Abstract
A compound of hyaluronate and protein (HP) isolated from synovial effusions in rheumatoid arthritis or gout showed unusual properties that distinguished it from normal HP. The HP from pathological effusions contained more protein (about 10%); remained immobilized at the origin during zone electrophoresis at pH 4.5; and formed a gel during dialysis in acetate buffer, pH 4.5. The integrity of both the hyaluronate and protein moieties was required for electrophoretic immobility and gel formation.Keywords
This publication has 5 references indexed in Scilit:
- The old and new concepts of acute gouty arthritisArthritis & Rheumatism, 1962
- Diarthrodial joints, an essayAmerican Journal Of Medicine, 1962
- ISOLATION OF HYALURONATEPROTEIN FROM HUMAN SYNOVIAL FLUID*JCI Insight, 1962
- Studies on human synovial membrane in vitro. The metabolism of normal and rheumatoid synovia and the effect of hydrocortisoneBiochemical Journal, 1958
- Synthesis of Hyaluronic Acid by Human Synovial Tissue SlicesScience, 1957