Cell surface immunoglobulin. XV. The presence of IgM and an IgD‐like molecule on the same cell in murine lymphoid tissue
- 1 February 1976
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 6 (2), 140-143
- https://doi.org/10.1002/eji.1830060215
Abstract
The present studies were designed to determine whether IgM and “IgD” are on the same cell in the mouse. Thus, radioiodinated murine lymphocytes were treated with anti-μ and complement to kill IgM-bearing cells. The dead cells were removed by gradient centrifugation. Results indicate that a portion of the IgD is removed by depleting IgM-bearing cells. Using cells from thoracic duct or lymph nodes but not spleen, it was evident that some of the double bearers are large lymphocytes.Keywords
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