Excretion of Free Histamine in Urine During Gastric Secretion Stimulated by Humoral Mechanisms

Abstract

This study was done to determine whether, after a meat meal, the outputs of acid in gastric juice and free histamine in urine are related and whether the output of free urinary histamine is increased after transplantation of the gastric antrum to the colon. Dogs with separated gastric pouches (Heidenhain) were used. Gastric juice and urine were collected at hourly intervals before and after the ingestion of the meal and for 24-hour periods before and after transplantation of the gastric antrum to the colon. Similar collections were made when histamine was injected intravenously at different rates. A rough temporal correlation was found between the outputs of HCl in gastric juice and free histamine in the urine after the meal of meat. There was not a significant increase in the 24-hour output of free histamine in the urine of the dogs in which a modest hypersecretion developed following transplantation of the gastric antrum to the colon.