Physiology of the Gastric Antrum

Abstract

The hypersecretion of gastric juice induced by transplantation of the antrum into the colon as a diverticulum is not due to the bacteria in the feces, since it is not reduced by sterilization of the intestinal content with sulfasuxidine and streptomycin. The hypersecretion of gastric juice induced by transplanting the antrum into the colon of dogs is lessened if a rim of acid-secreting body mucosa is left attached to the antrum transplant. Subsequent removal of this acid-secreting mucous membrane from the transplant augments gastric secretion from the isolated fundic pouch. The theory of acid inhibition of the gastric phase of secretion proposed by Wilhelmi is supported. The application of ground liver or horse-meat to isolated antrum pouches produced secretion from pouches of the gastric fundus provided the test substances were not acid in reaction. The application of acid solns. to isolated antrum pouches inhibited the continuous secretion from the gastric fundus.