UPTAKE OF 35S-SULPHATE BY HEALING WOUNDS

Abstract

The experiments reported alterations in the amount of sulphated mucopolysaccharide present during the healing of normal skin wounds and to what extent this was affected by thyroxine and by ascorbic acid deficiency. The rate and intensity of S35-sulphate incorporation into sound tissue was studied in untreated guinea pigs and in guinea pigs treated with thyroxine or with a scorbutogenic diet. The utilization of available sulphates in scorbutic wounds was better than in control animals. In thyroxine treated animals, this utilization seemed to be inhibited.