Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis
- 1 September 1987
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 209 (2), 374-381
- https://doi.org/10.1007/bf00329668
Abstract
Insertion of the transposable element Ty at the ADH4 locus results in increased levels of a new alcohol dehydrogenase (ADH) activity in Saccharomyces cerevisiae. The DNA sequence of this locus has been determined. It contains a long open reading frame which is not homologous to the other ADH isozymes that have been characterized in S. cerevisiae nor does it show obvious homology to Drosophila ADH. The hypothetical ADH does, however, show strong homology to the sequence of an iron-activated ADH from the bacterium Zymomonas mobilis. Thus ADH4 appears to encode an ADH structural gene which, along with the Zymomonas enzyme, may define a new family of alcohol dehydrogenases.This publication has 43 references indexed in Scilit:
- Resistance to antimycin A in yeast by amplification of ADH4 on a linear, 42 kb palindromic plasmidCell, 1986
- The two alcohol dehydrogenases of Zymomonas mobilis. Purification by differential dye ligand chromatography, molecular characterisation and physiological rolesEuropean Journal of Biochemistry, 1986
- The SPT3 gene is required for normal transcription of Ty elements in S. cerevisiaeCell, 1984
- Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeastCell, 1984
- DNA sequences of two yeast promoter-up mutantsNature, 1983
- An iron‐activated alcohol dehydrogenaseFEBS Letters, 1983
- A positive regulatory gene is required for accumulation of the functional messenger RNA for the glucose-repressible alcohol dehydrogenase from Saccharomyces cerevisiaeJournal of Molecular Biology, 1981
- Transposable elements associated with constitutive expression of yeast alcohol dehydrogenase IICell, 1981
- Isolation of the structural gene for alcohol dehydrogenase by genetic complementation in yeastNature, 1980
- Genetics of alcohol dehydrogenase in Saccharomyces cerevisiae: I. Isolation and genetic analysis of adh mutantsMutation Research, 1975