Delayed aggregation of proteoglycans in adult human articular cartilage
- 1 October 1984
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 4 (10), 827-833
- https://doi.org/10.1007/bf01138164
Abstract
The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of proteoglycans into the extraceHular matrix may be controlled.This publication has 15 references indexed in Scilit:
- Differences in the rates of aggregation of proteoglycans from human articular cartilage and chondrosarcomaBiochemical Journal, 1983
- Structure of proteoglycans from different layers of human articular cartilageBiochemical Journal, 1983
- The role of link-protein in the structure of cartilage proteoglycan aggregatesBiochemical Journal, 1979
- Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronateBiochemical Journal, 1976
- Aggregation of Cartilage ProteoglycansJournal of Biological Chemistry, 1974
- Aggregation of Cartilage ProteoglycansPublished by Elsevier ,1974
- Sulphate diffusion and incorporation into human articular cartilageBiochimica et Biophysica Acta (BBA) - General Subjects, 1974
- Patterns of cartilage stiffness on normal and degenerate human femoral headsJournal of Biomechanics, 1971
- Proteinpolysaccharide Complex from Bovine Nasal CartilagePublished by Elsevier ,1969
- A modified uronic acid carbazole reactionAnalytical Biochemistry, 1962