Inositol 1,4,5‐trisphosphate and 5′‐GTP induce calcium release from different intracellular pools

Abstract

It has been shown recently by several groups that 5′-GTP can release calcium from intracellular compartments independently from inositol 1,4,5-trisphosphate (Ins(1,4,5)P₃) by a mechanism which seems to be different from that used by Ins(1,4,5)P₃. We report here for the first time that the 5′-GTP-sensitive and the Ins(1,4,5)P₃-sensitive calcium pools reside in different intracellular compartments.