Liver Necrosis in Mice Following Injection of Toxic Extracts of Progestational Endometrium and of Placenta

Abstract

Focal liver necrosis occurred in 30% of 500 mice which survived the intravenous injn. of single sub-lethal quantities of toxic extracts of endometrium or placenta. Occasional similar lesions were seen in mice which were in-jected with other tissue extracts. Although related to the effect of the injected toxic material from endometrium or placenta, the lesions may be indirect or non-specific effects of the injns.