Renotropic Effects of Growth Hormone Preparations

Abstract

Two of 4 growth hormone prepns. in daily doses of 0.42 to 0.5 mg./kg. have been renotropically active in normal and hypophysectomized dogs, in that they have greatly increased PAH and inulin clearances and, where tested, TmPAH; they have also raised oxygen consumption. A 5th preparation was very potent? in hypophysectomized dogs. These effects are not due to contaminant thyrotropin, ACTH or gonadotropins. The most active prepns. have been the purest. The 2 prepns. which were without renotropic effect in normal dogs have been active in hypophysectomized dogs. At least part of this activity can be attributed to the thyrotropin content of these less-pure prepns. No evidence for a hitherto undescribed renotropically active contaminant present in the active prepns. and absent from the inactive, or for an inhibitor present in the inactive, has been obtained, although these possibilities have not been excluded. The authors favor the view that the renotropic effects observed are due to growth hormone or to some substance not yet separated from it.