Gene Silencing by siRNA Microhydrogels via Polymeric Nanoscale Condensation
- 16 August 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (35), 13914-13917
- https://doi.org/10.1021/ja2056984
Abstract
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanopartides that exhibited superb cellular uptake efficiency and gene silencing activity.This publication has 45 references indexed in Scilit:
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