Absorption of Medium Chain Triglycerides in Tropical Sprue

Abstract

Summary The absorption of medium chain triglycerides (MCT) has been studied in 8 patients with tropical sprue (2 acute, 4 in relapse, 2 in remission). Studies were performed first during a period in which a standard steatorrhea test diet containing long chain animal and vegetable fats was given, and continued while substituting all the fat in the diet for medium chain triglycerides. Normal fat excretion levels were attained by all patients while they were receiving from 80-100 g of medium chain triglycerides in the diet. The average apparent coefficient of fat absorption ranged from 92.3 to 97%. Steatorrhea recurred when the steatorrhea test diet was repeated, and disappeared again when the MCT diet was resumed. Absorption of medium chain triglycerides was accompanied by improved appetite, weight gain, and increased serum lipids. The results of this experiment suggest that medium chain triglycerides may have a place in the management of sprue cases. The authors are indebted to Dr. V. K. Babayan, E. F. Drew Chemical Co., for supplying MCT oil; to Drs. C. F. Asenjo, E. Toro-Goyco and J. V. Rivera for valuable suggestioms; to Dr. M. Martínez-Maldo-nado, Mrs. G. Muñoz, Mrs. B. González, Mr. B. Calderón, Mr. J. M. León for professional assistance.