THE EFFECTS OF THE PITUITARY GROWTH AND ADRENOCORTICOTROPIC HORMONES ON THE URINARY GLUCOSE AND NITROGEN OF DIABETIC RATS

Abstract

Rats with persistent alloxan-diabetes were maintained on a constant food intake and urinary glucose and nitrogen were detd. daily. The effects of 1 mg. and 3 mg./day of growth and of adrenocorticotrophic hormones were studied both with and without the addition of exogenous insulin. At both levels of admn. and both with and without exogenous insulin, growth hormone produced nitrogen retention. Only at the higher dose did growth hormone affect the glycosuria, increasing it in 1/3 of the cases. One mg./day of adrenocorticotrophic hormone was without effect, but 3 mg./day increased the glycosuria and N excretion, both with and without exogenous insulin. The increase in glycosuria produced by adrenocorticotrophic hormone was greater than could be accounted for by gluconeogenesis from the increased protein breakdown.