Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease
Open Access
- 14 January 1993
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (2), 73-80
- https://doi.org/10.1056/nejm199301143280201
Abstract
Hydroxyurea increases the production of fetal hemoglobin in patients with sickle cell anemia, inhibiting the polymerization of hemoglobin S and potentially improving vaso-occlusive manifestations and hemolysis. Recombinant erythropoietin increases the number of reticulocytes containing fetal hemoglobin in laboratory animals and in humans. We studied whether hydroxyurea and erythropoietin might have a potentiating effect on the production of fetal hemoglobin in patients with sickle cell disease.Keywords
This publication has 25 references indexed in Scilit:
- Consideration of Pharmacokinetics and Temporal Sensitivity for Hydroxyurea in Relation to Teratogenic PotentialJournal of the American College of Toxicology, 1991
- Hematologic Responses of Patients with Sickle Cell Disease to Treatment with HydroxyureaNew England Journal of Medicine, 1990
- Anemia of PrematurityJournal of Pediatric Hematology/Oncology, 1990
- Levels of Fetal Hemoglobin Necessary for Treatment of Sickle Cell DiseaseNew England Journal of Medicine, 1988
- Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in BaboonsNew England Journal of Medicine, 1987
- Correction of the Anemia of End-Stage Renal Disease with Recombinant Human ErythropoietinNew England Journal of Medicine, 1987
- Stimulation of F-Cell Production in Patients with Sickle-Cell Anemia Treated with Cytarabine or HydroxyureaNew England Journal of Medicine, 1985
- Experience with cholelithiasis in patients with sickle cell disease in NigeriaJournal of Pediatric Hematology/Oncology, 1985
- Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.Journal of Clinical Investigation, 1984
- Individual Variation in the Production and Survival of F Cells in Sickle-Cell DiseaseNew England Journal of Medicine, 1978