Roles of kallikrein-kinin system in acute inflammation: Studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain)
- 1 August 1987
- journal article
- mediators of-acute-inflammation
- Published by Springer Nature in Inflammation Research
- Vol. 21 (3-4), 384-386
- https://doi.org/10.1007/bf01966523
Abstract
Carrageenin-induced paw edema in HMW- and LMW-kininogens-deficient rats was significantly less than that in normal rats. There are three kiniogens, HMW-, LMW- and T-kininogens, in normal rat plasma, but B/N-Katholiek rat plasma contains only T-kininogen. The pretreatment with captopril, a kiniase II inhibitor, enhanced paw swelling of normal rats, but not that of the deficient rats, indicating that bradykinin released from HMW-kininogen may have a role for the swelling but T-kinin may not be released in this inflammation.Keywords
This publication has 10 references indexed in Scilit:
- Evidence for a role of the plasma kallikrein-kinin system in acute inflammation: reduced exudation during carrageenin- and kaolin-pleurisies in kininogen-deficient ratsInflammation Research, 1986
- A radioimmunoassay for rat T-kininogen as an acute phase reactant.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
- Primary structures of the mRNAs encoding the rat precursors for bradykinin and T-kinin. Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor.Journal of Biological Chemistry, 1985
- Identification of T-kininogen in high and low molecular weight kininogens deficient rat (Brown Norway Katholiek strain)Thrombosis Research, 1985
- Demonstration of the third kininogen in high and low molecular weight kininogens-deficient brown norway katholiek ratThrombosis Research, 1984
- Prolonged activated partial thromboplastin time and deficiency of high molecular weight kininogen in brown norway rat mutant (Katholiek strain)Thrombosis Research, 1984
- THE ROLE OF THE KININ SYSTEM IN VARIOUS INFLAMMATORY MODELS IN THE RAT1984
- Isolation and structure of T-kininBiochemical and Biophysical Research Communications, 1983
- Congenital deficiency in plasma kallikrein and kininogens in the brown Norway ratCellular and Molecular Life Sciences, 1980