Effects of Hyperthermia, Radiotherapy and Thermoradiotherapy on Tumor Microvascular Permeability
- 1 February 1990
- journal article
- research article
- Published by Wiley in Acta Pathologica Japonica
- Vol. 40 (2), 79-84
- https://doi.org/10.1111/j.1440-1827.1990.tb01546.x
Abstract
Morphological changes in rabbit VX-2 tumor and its vascular permeability to ferritin following hyperthermia, radiotherapy and thermoradiotherapy were investigated by light and electron microscopy. Tumors treated by thermoradiotherapy successively showed a decrease in volume compared with those treated by hyperthermia or radiotherapy. Light microscopically, degenerative or necrotic changes progressed more widely in tumors treated by thermoradiotherapy than in those treated by hyperthermia or radiotherapy alone. When vascular permeability occurred at 1 day after hyperthermia or thermoradiotherapy, and at 3 days after radiotherapy. These results suggest that the early reaction of tumor microvasculature is a factor contributing to delayed cell death in tumors after thermoradiotherapy or hyperthermia.Keywords
This publication has 17 references indexed in Scilit:
- Hyperthermia-induced vascular injury in normal and neoplastic tissueCancer, 1985
- Blood flow changes in transplanted mouse tumours and skin after mild hyperthermiaThe British Journal of Radiology, 1983
- Effect of hyperthermia, radiation and adriamycin combinations on tumor vascular functionInternational Journal of Radiation Oncology*Biology*Physics, 1982
- Histopathological study on the effects of hyperthermia on microvasculatureInternational Journal of Radiation Oncology*Biology*Physics, 1981
- Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating.Radiology, 1980
- The effect of hyperthermia on vascular function, pH, and cell survival.Radiology, 1980
- Alterations in tumor microvasculature during hyperthermia.Radiology, 1980
- EFFECT OF HYPERTHERMIA ON VASCULAR FUNCTION IN NORMAL AND NEOPLASTIC TISSUES*Annals of the New York Academy of Sciences, 1980
- The response of six mouse tumours to combined heat and X rays: implications for therapyThe British Journal of Radiology, 1979