The Failure of Thyroxine and High-Fat Diets to Modify the Rate of Thiamine Loss from the Body

Abstract

Young adult mice were fed thiamine-free diets containing 5 and 20% fat as well as the 5% fat diet supplemented with 25 mg of thyroxine per kilogram of diet. Liver and total body thiamine and cocarboxylase were determined at intervals. Although the thryoxine hastened weight loss and time of death and the high-fat diet showed the reverse effect, no difference in the rate of loss of thiamine from the liver or carcass was found. It is concluded that the rate of thiamine loss is dependent upon the thiamine content of the body or tissues and essentially independent of the diet fed.