Acute Tubular Necrosis

Abstract

A case of acute tubular necrosis secondary to carbon tetrachloride inhalation is described. The patient survived 67 days of oliguria with a urinary output never in excess of 350 ml per 24 hr. Renal biopsies performed on the 38th and 64th hospital days showed regenerating renal tubular epithelium, but, despite the histological evidence of recovery the clinical course was one of persistent oliguria. The significance of the functional and histological findings and the pertinent features of the therapy are discussed.