Effects of Shock and Gold on Mouse Liver Sulfhydryl.

Abstract

Protein-containing and protein-free mouse liver extracts were prepared and aliquots titrated for total and non-protein sulfhydryl by the amperometric method. Mice were subjected to severe stress by scalding, ligation trauma, injn. of a toxic dose of a bacterial polysaccharide, or exposure to cold. Each of these procedures produced a marked decrease in liver non-protein sulfhydryl concn. In some expts., a moderate decrease in liver protein sulfhydryl concn. also occurred. Mice recovering from scalding exhibited marked increases in liver non-protein sulfhydryl concn., to values well above the original control level.