THE REMOVAL OF DIODRAST FROM BLOOD BY THE DOG'S EXPLANTED KIDNEY

Abstract

Diodrast intravenously in-fused in dogs is unequally distributed between the plasma and red blood cells, the distribution ratio between cell and plasma water being approx. 0.50. At low renal loads, the extraction of diodrast from arterial plasma during its passage through the explanted kidneys of dogs averaged 0.84. Diodrast extraction was not affected by uninephrectomy. Renal extraction of diodrast from arterial red blood cells averaged 0.20. The removal of diodrast from arterial blood by the dog''s explanted kidney is such that at low renal loads the ratio [image] is approx. 0.87.