SIMULTANEOUS PLASMA CLEARANCES OF CREATININE AND CERTAIN ORGANIC COMPOUNDS OF IODINE IN RELATION TO HUMAN KIDNEY FUNCTION 1

Abstract

The clearances of 3 organic compounds of I were compared with simultaneous creatinine clearances. In normal subjects skiodan and creatinine clearances were of the same order of magnitude. Neo-skiodan and hippuran clearances were significantly greater than creatinine clearances; the differences were so conspicuous that the elimination of these 2 I compounds can not be explained by simple glomerular filtration, but must be ascribed in part to tubular activity. In renal insufficiency hippuran clearances were in general reduced proportionately to urea clearances, creatinine clearances and concentrating power. Hippuran clearances were related more closely to the grade of renal insufficiency as a whole than to preponderance of glomerular or tubular dysfunction; they remained greater than creatinine clearances even in advanced renal failure. The plasma clearances of these organic compounds of I, while of considerable physiological interest, provide no special information to recommend their use in the diagnosis or clinical study of renal disease.