Depression of phagocytic activity and immune response by methyl palmitate
- 1 May 1964
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 206 (5), 939-943
- https://doi.org/10.1152/ajplegacy.1964.206.5.939
Abstract
Intravenous administration of methyl palmitate produced a marked depression of the phagocytic activity of the RES. Histological evidence indicates that the RE-depressant effect exerted by methyl palmitate is not due to destruction of RE cellular elements but rather to an interference with the phagocytic activity of Kupffer cells. The functional activity of parenchymal cells was unaltered in RE hypofunctional mice. A depressed functional state of the RES, existing at the time of antigenic challenge with sheep erythrocytes, was associated with a profound inhibition of antibody formation during the primary and secondary immune response. This reduced antibody formation was not associated with alterations in the total circulating leukocyte level nor in the percentage of lymphocytes in peripheral blood. The employment of methyl palmitate to produce phagocytic and immunological paralysis is proposed.Keywords
This publication has 15 references indexed in Scilit:
- Effect of removal of lymphatic tissue on immune response in miceAmerican Journal of Physiology-Legacy Content, 1961
- Identification of a reticuloendothelial stimulating agent in zymosanAmerican Journal of Physiology-Legacy Content, 1961
- The effect of 5-bromouracil deoxyriboside on the synthesis of antibody in vitroBiochemical Journal, 1960
- Proliferation of the reticuloendothelial system in the liverAmerican Journal of Physiology-Legacy Content, 1960
- THE EFFECT OF 6-MERCAPTOPURINE ON PRIMARY AND SECONDARY IMMUNE RESPONSES *JCI Insight, 1959
- THE EFFECT OF HIGH DOSES OF X-IRRADIATION ON THE PHAGOCYTIC, PROLIFERATIVE, AND METABOLIC PROPERTIES OF THE RETICULO-ENDOTHELIAL SYSTEMThe Journal of Experimental Medicine, 1959
- The Clearance of Antigen Antibody Complexes from the Blood by the Reticulo-Endothelial SystemThe Journal of Immunology, 1959
- Phagocytosis of Foreign Red Blood Cells by the Reticulo-Endothelial SystemAmerican Journal of Physiology-Legacy Content, 1957
- CORTISONE AND PHAGOCYTOSISEndocrinology, 1955
- SYNTHESIS OF ALL PLASMA PROTEIN FRACTIONS EXCEPT GAMMA GLOBULINS BY THE LIVERThe Journal of Experimental Medicine, 1954