Embryogenesis of the Inner Ear: Ii.The Late Differentiation of the Mammalian Crista Ampullaris in Vivo and in Vitro
- 31 December 1982
- journal article
- research article
- Published by Taylor & Francis in Acta Oto-Laryngologica
- Vol. 96 (1-2), 1-8
- https://doi.org/10.3109/00016488309132868
Abstract
The embryonic development of the crista ampullaris of the CBA/CBA mouse was followed both in organ culture of explanted inner ears of the 16th gestation-al day and in vivo from the 16th gestational day until the 21st day, an age corresponding to birth. Cytodifferentiation of the sensory epithelium of the crista ampullaris occurs during this period. At partus, there is a rather mature crista with well developed hair cells and 1–2 layers of supporting cells. Innervation and differentiation into type I and type II hair cells have started prior to partus but occur mainly post partum. The in vitro development followed that of the in vivo but with a slight delay, especially concerning the later stages of the in vitro development. At the time corresponding to partus, differentiation of hair cells is almost identical in the two groups but innervation is delayed in the in vitro group of inner ears. Because of the very high reproducibility/stability in vitro and morphologic maturation of both hair cells and gross structure of the crista ampullaris, organ culture of the 16th gestational day inner ear explant is a suitable model in the study of the late embryonic development under normal and pathological conditions.This publication has 18 references indexed in Scilit:
- Embryogenesis of the inner earArchives of Oto-Rhino-Laryngology, 1979
- Organ Culture of the 16th Gestation Day Mouse Labyrinth:A Model Suggestion for Pre- and Post-partum DevelopmentActa Oto-Laryngologica, 1978
- Organotypic development of the organ of Corti in cultureJournal of Neurocytology, 1975
- Organ Culture of the Mammalian Inner EarActa Oto-Laryngologica, 1971
- Development of cochlear function in the ear of the infant rat.Journal of Comparative and Physiological Psychology, 1966
- The Development of the Organ of Corti in the MouseActa Oto-Laryngologica, 1965
- Development of mammalian endocochlear potentialJournal of Experimental Zoology, 1963
- Electron Microscope Observations on in Vitro Cultures of the Isolated Fowl Embryo OtocystThe Journal of cell biology, 1959
- ZUR KENNTNIS DER DIFFERENZIERUNGSVORGÄNGE IM EPITHEL DES DUCTUS COCHLEARISCells Tissues Organs, 1957
- In vitro studies of cartilage induction in mouse somite mesodermJournal of Experimental Zoology, 1955