THE HAEMODYNAMIC AND METABOLIC EFFECTS OF MG 8926, A PROSPECTIVE ANTIDYSRHYTHMIC AND ANTIANGINAL AGENT

Abstract

1The antidysrhythmic, haemodynamic and metabolic effects of a new prospective antianginal and antidysrhythmic agent, N-(3,3-diphenylpropyl)-α-methyl-β-cyclohexylethylamine hydrochloride (MG 8926), have been compared with the chemically related substance, prenylamine, in anaesthetized greyhounds and guinea-pigs. 2When given intravenously 20 min beforehand, both MG 8926 and prenylamine (5 mg/kg) significantly suppressed the early dysrhythmias induced by coronary artery ligation in anaesthetized greyhounds. At a dose of 1 mg/kg, MG 8926 also protected anaesthetized guinea-pigs from dysrhythmias induced by ouabain infusions. 3In dogs pretreated with MG 8926, metabolic changes indicative of myocardial ischaemia (increased Pco₂ and potassium efflux, decreased oxygen content and pH) were less marked than those occurring in control animals. 4Evidence was obtained that MG 8926, when given either before or after coronary occlusion, was capable of decreasing the severity of myocardial ischaemia as assessed by ST-segment changes in epicardial electrocardiograms.