THE EFFECT OF MENGOVIRUS INFECTION ON THE ACTIVITY OF THE DNA-DEPENDENT RNA POLYMERASE OF L-CELLS
- 1 August 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (8), 1383-1390
- https://doi.org/10.1073/pnas.48.8.1383
Abstract
Infection of L-cells with Mengovirus causes a marked decrease in the activity of DNA-dependent RNA-polymerase (aggregate-enzyme). A decrease in the enzyme activity was seen in in vivo nuclear RNA synthesis and in the activity of isolated nuclei or aggregate enzyme. Actinomycin inhibited DNA-dependent RNA synthesis in the aggregate enzyme fraction obtained from L-cells.Keywords
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