A Robertsonian Type of Chromosomal Change in L4946 Mouse Ascites Lymphoma2
- 1 May 1960
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 24 (5), 1187-1197
- https://doi.org/10.1093/jnci/24.5.1187
Abstract
L4946 ascites lymphoma of AKR mice had maintained the karyotype consisting of 41 acrocentric chromosomes for 18 months in our laboratory. Suddenly a large mediocentric chromosome and a heterochromatic minute were formed, apparently at the expense of two acrocentric chromosomes, providing a classic example of a Robertsonian relationship manifesting itself within the neoplastic cell population of a transplantable tumor. The sensitivity to breakage of centromeric heterochromatic regions of the acrocentric chromosomes has been considered as a cause of this type of karyological evolution.Keywords
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